HoLMiR’s second research focus revolves around various aspects of animal health. The intestinal mucosa is at the center of these investigations. As the interface between animal and microbiome, it also controls the interaction between microorganisms and the host animal. This influences a variety of bodily functions - from the immune system to neuronal processes and animal behavior. It is also crucial for nutrient uptake and thus for which substances are excreted as environmental pollutants.
At the same time, the intestinal mucosa and microbiome form the crucial barrier against pathogens and control the activity of immune cells. Insights into this complex are therefore key for strategies to improve animal health and reduce the use of antibiotics.
The issue is further complicated by the fact that pathogens also change their toxicity with the environment. This means that the availability of nutrients and metabolites in the gut, as well as the desirable microbes, help determine whether a pathogen poses any threat at all. Findings on this topic could lead to new strategies for the prevention and therapy of infectious diseases.
Read more about a selection of our projects on this research focus.
